Dr. Howe and Dr. Fish
Dr. Fish
Dr. Howe and Dr. Fish
- Schulz K, Botts SR, Ellis K, Scipione CA, Khyza N, Ho C, Kumaragurubaran R, Yuki KE, Wythe J, Miller C, Wilson MD, Howe KL, Fish JE. ERG is a regulator of dynamic and reversible endothelial plasticity. Genome Med 18, 53 (2026). https://doi.org/10.1186/s13073-026-01638-6
- Raju S, Turner ME, Cao C, Abdul-Samad M, Punwasi N, Blaser MC, Cahalane RM, Botts SR, Prajapati K, Patel S, Wu R, Gustafson D, Galant NJ, Fiddes L, Chemaly M, Hedin U, Matic L, Seidman M, Subasri V, Singh SA, Aikawa E, Fish JE, Howe KL. Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks. Arteriosclerosis, Thrombosis, and Vascular Biology. 2025 May 29. https://www.ahajournals.org/doi/10.1161/ATVBAHA.124.322324
- Guo MK, Scipione CA, Breda LC, Prajapati K, Raju S, Botts SR, Abdul-Samad M, Patel S, Yu G, Dudley A C, Fish JE, Howe, KL. Tracking endothelial extracellular vesicles in a mouse model of atherosclerosis. Circulation Research. 2025 April 23. https://doi.org/10.1161/circresaha.124.326024
- Patel S, Ellis K, Scipione CA, Fish JE, Howe KL. Epigallocatechin gallate (EGCG) modulates senescent endothelial cell-monocyte communication in age-related vascular inflammation. Front. Cardiovasc. Med. 2025;11:1506360. doi: 10.3389/fcvm.2024.1506360
- Raju S, Botts S, Blaser M, Abdul-Samad M, Prajapati K, Khosraviani N, Ho TWW, Breda LCD, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish J, Howe KL. Directional endothelial communication by polarized extracellular vesicle release. Circulation Research. 2024 Jan 4. https://doi.org/10.1161/CIRCRESAHA.123.322993
- Hanneman K, Houbois C, Kei T, Gustafson D, Thampinathan B, Sooriyakanthan M, Fish JE, Howe KL, Cheung AM, Wintersperger BJ, Gold WL, Woo A, Thavendiranathan P. Multimodality cardiac imaging, cardiac symptoms, and clinical outcomes in patients who recovered from mild COVID-19. Radiology. 2023 Jul;308(1):e230767. doi: 10.1148/radiol.230767. PMID: 37432085.
- Patel S, Guo MK, Abdul Samad M, Howe KL. Extracellular vesicles as biomarkers and modulators of atherosclerosis pathogenesis. Front Cardiovasc Med. 2023 May 26;10:1202187. doi: 10.3389/fcvm.2023.1202187. PMID: 37304965; PMCID: PMC10250645.
- Guo X, Khosraviani N, Raju S, Singh J, Farahani NZ, Abramian M, Torres VJ, Howe KL, Fish JE, Kapus A, Lee WL. Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles. Front Immunol. 2023 Apr 21;14:1181016. doi: 10.3389/fimmu.2023.1181016. PMID: 37153544; PMCID: PMC10160463.
- Marschner CA, Thavendiranathan P, Gustafson D, Howe KL, Fish JE, Iwanochko RM, Wald RM, Abdel-Qadir H, Epelman S, Cheung AM, Hong R, Hanneman K. Myocardial Inflammation on FDG PET/MRI and Clinical Outcomes in Symptomatic and Asymptomatic Participants after COVID-19 Vaccination. Radiol Cardiothorac Imaging. 2023 Mar 9;5(2):e220247. doi: 10.1148/ryct.220247. PMID: 36987440; PMCID: PMC10037313.
- Howe KL, Cybulsky M, Fish JE. The Endothelium as a Hub for Cellular Communication in Atherogenesis: Is There Directionality to the Message? Front Cardiovasc Med. 2022 Apr 15;9:888390. doi: 10.3389/fcvm.2022.888390. PMID: 35498030; PMCID: PMC9051343.
- Gustafson D, Ngai M, Wu R, Hou H, Schoffel AC, Erice C, Mandla S, Billia F, Wilson MD, Radisic M, Fan E, Trahtemberg U, Baker A, McIntosh C, Fan CS, Dos Santos CC, Kain KC, Hanneman K, Thavendiranathan P, Fish JE, Howe KL. Cardiovascular signatures of COVID-19 predict mortality and identify barrier-stabilizing therapies. EBioMedicine. 2022 Apr;78:103982. doi: 10.1016/j.ebiom.2022.103982. Epub 2022 Apr 8. PMID: 35405523; PMCID: PMC8989492.
- Lu, RXZ, Lai BFL, Rafatian N, Gustafson D, Campbell SB, Banerjee A, Kozak R, Mossman K, Mubareka S, Howe KL, Fish JE, Radisic M. 2022. Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation. Lab on a chip, 22(6), 1171–1186. https://doi.org/10.1039/d1lc00817j
- Hanneman K, Houbois C, Schoffel A, Gustafson D, Iwanochko RM, Wintersperger BJ, Chan R, Fish JE, Howe KL, Thavendiranathan P. Combined Cardiac Fluorodeoxyglucose-Positron Emission Tomography/Magnetic Resonance Imaging Assessment of Myocardial Injury in Patients Who Recently Recovered From COVID-19. JAMA Cardiol. 2022 Mar 1;7(3):298-308. doi: 10.1001/jamacardio.2021.5505. PMID: 35019953; PMCID: PMC8756363.
- Veitch S, Njock MS, Chandy M, Siraj MA, Chi L, Mak H, Yu K, Rathnakumar K, Perez-Romero CA, Chen Z, Alibhai FJ, Gustafson D, Raju S, Wu R, Zarrin Khat D, Wang Y, Caballero A, Meagher P, Lau E, Pepic L, Howe KL, … Fish JE. MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes. Cardiovascular diabetology. 2022 Feb; 21(1), 31. https://doi.org/10.1186/s12933-022-01458-z
- Botts SR, Fish JE, Howe KL. Dysfunctional Vascular Endothelium as a Driver of Atherosclerosis: Emerging Insights Into Pathogenesis and Treatment. Front Pharmacol. 2021 Dec 22;12:787541. doi: 10.3389/fphar.2021.787541. PMID: 35002720; PMCID: PMC8727904
Dr. Fish
Trainees underlined.
- Wu R, Khosraviani K, Mansur A, Boudreau E, Largoza GE, Park S, Gustafson D, Raju S, Ching C, Klip A, Walchli T, Howe KL, Radovanovic I, Wythe JD, Fish JE. KRAS-dependent glycolytic reprogramming of endothelial cells in sporadic arteriovenous malformations. EMBO Molecular Medicine. 2026 Feb 18. E-Pub ahead of print. 10.1038/s44321-026-00383-y
- *Gustafson D, *Mistry P, Ching C, Nardi-Agmon I, Yu C, Fan CP, Houbois C, Amir E, Marwick T, Abdel-Qadir H, McIntosh C, #Thavendiranathan P, #Fish JE. Pre-treatment circulating vascular biomarkers predict cancer therapy-related cardiac dysfunction during HER2+ breast cancer treatment. JACC:CardioOncology. 2025 Dec;7(7):870-885. *Co-first author; #Co-corresponding author. 10.1016/j.jaccao.2025.09.004
- Walchli T, Ghobrial M, Schwab M, Takada S, Zhong H, Suntharalingham S, Vetiska S, Gonzalez DR, Rehrauer H, Wu R, Yu K, Bisschop J, Farnhammer F, Regli L, Schaller K, Frei K, Ketela T, Bernstein M, Kongkham P, Carmeliet P, Valiante T, Dirks PB, Suva ML, Zadeh G, Tabar V, Schlapbach R, De Bock K, Fish JE, Monnier PP, Bader GD, Radovanovic I. Molecular atlas of the human brain vasculature across development, adulthood and disease at the single-cell level. Nature. 2024 Aug; 632(8025):603-613. 10.1038/s41586-024-07493-y
- *Gustafson D, *DiStefano PV, Wang XF, Wu R, Ghaffari S, Ching C, Rathnakumar K, Alibhai F, Syonov M, Fitzpatrick J, Boudreau E, Lau C, Galant N, Husain M, Li RK, Lee WL, Parekh R, Monnier P, Fish JE. Circulating small extracellular vesicles mediate diabetic vascular hyperpermeability. Diabetologia. 2024 Jun; 67(6):1138-1154. *Co-first authors, equal contribution. 10.1007/s00125-024-06120-9
- Soon K, Li M, Wu R, Zhou A, Khosraviani N, Turner WD, Wythe JD, Fish JE, Nunes SS. A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks. Biomaterials. 2022 Sep;288:121729. http://doi.org/10.1016/j.biomaterials.2022.121729
- Gustafson D, Ngai M, Wu R, Hou H, Schoffel A, Erice C, Mandla S, Billia F, Wilson MD, Radisic M, Fan E, Trahtemberg U, Baker A, McIntosh C, Fan CPS, dos Santos CC, Kain KC, Hanneman K, Thavendiranathan P, *Fish JE, *Howe KL. Cardiovascular signatures of COVID-19 predict mortality and identify barrier stabilizing therapies. EBioMedicine. 2022 Apr;78:103982. *Co-corresponding authors. http://doi.org/10.1016/j.ebiom.2022.103982
- Veitch S, Njock MS, Chandy M, Siraj MA, Chi L, Chen Z, Alibhai FJ, Gustafson D, Raju S, Wu R, Rathnakumar K, Khat DZ, Caballero A, Meagher P, Lau E, Pepic L, Cheng HS, Galant NJ, Howe KL, Li RK, Connelly KA, Delgado-Olguin P, Husain M, Fish JE. MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes. Cardiovascular Diabetology. 2022; 21(1):31. http://doi.org/10.1186/s12933-022-01458-z
- *Alizada A, *Khyzha N, Wang L, Antounians L, Chen X, Khor M, Liang M, Rathnakumar K, Weirauch MT, Medina-Rivera A, #Fish JE, #Wilson MD. Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals. Nature Communications. 2021 Jan 25; 12(1):567. *Equal contribution, #Co-corresponding author, equal contribution. http://doi.org/10.1038/s41467-020-20765-1
- *#Fish JE, #Flores-Suarez CP, #Boudreau E, Herman AM, Gutierrez MC, Gustafson D, DiStefano PV, Cui M, Chen Z, Berman De Ruiz K, Schexnayder TS, Ward CS, Radovanovic I, *Wythe JD. Somatic gain of KRAS function in the endothelium is sufficient to cause vascular malformations that require MEK but not PI3K signaling. Circulation Research. 2020 Aug 28;127(6):727-743. *Corresponding authors, equal contribution. #Co-principal author, *Co-corresponding Author. http://doi.org/10.1161/CIRCRESAHA.119.316500
- Khyzha N, Khor M, DiStefano P, Wang L, Matic L, Hedin U, Wilson MD, Maegdefessel L and Fish JE. Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA. Proceedings of the National Academy of Sciences. 2019 Aug 13; 116(33):16410-16419. http://doi.org/10.1073/pnas.1904108116
- *Nikolaev SI, Vetiska S, Bonilla X, Boudreau E, Jauhiainen S, Jahromi BR, Khyzha N, DiStefano P, Suutarinen MB, Kiehl TM, Pereira VM, Antonarakis SE, Krings T, Andrade-Barazarte H, Tung T, Valiante T, Zadeh G, Tymianski M, Antonarakis SE, Wythe JD, Rauramaa T, Yla-Herttuala S, *Frosen J, *Fish JE, *Radovanovic I, Somatic activating KRAS mutations in arteriovenous malformations of the brain. New England Journal of Medicine. 2018 Jan 18;378(3):250-261. *Corresponding authors, equal contribution. http://doi.org/10.1056/NEJMoa1709449